ImPACT Therapy - Powerful "Off-The-Shelf" Immune Activation
Heat Biologics' novel off-the-shelf Immune Pan-Antigen Cytotoxic Therapy (“ImPACT” Therapy) is a therapeutic vaccine platform designed to combat a wide range of cancers and infectious diseases. Our ImPACT therapy utilizes live, off-the-shelf, genetically modified cells as an "antigen delivery system" to elicit a robust and powerful immune response against targeted disease. ImPACT Therapy transforming allogeneic living cells into powerful machines that continually pump-out heat shock proteins and their chaperoned antigens to activate the immune system against the full-spectrum of antigens expressed by a patient’s disease.
In contrast to other vaccine technologies, Heat's novel shotgun approach enables the body to induce and maintain an immune response against multiple tumor proteins, thus unleashing a powerful multi-prong attack against the tumor. Clinical and pre-clinical results indicate that the ImPACT Therapy generates a potent anti-tumor immune response that fights targeted tumors and keeps the body tumor-free even when re-challenged with the cancer. This novel live cell vaccine approach is applicable to a wide array of viral infections as well as cancer, HIV, HCV, Flu and other diseases. Heat's approach is an off-the-shelf product that does not require invasive surgery or isolation of patient tissues.
Clinical Development
Heat has initiated an aggressive development program to target its ImPACT Therapy against a range of diseases. Heat is currently in Phase II clinical trials with its first ImPACT Therapy based product, HS-110, a treatment for Non-Small Cell Lung Cancer (NSCLC) and is working to initiate additional ImPACT Therapy-based clinical trials for ovarian and pancreatic cancers. ImPACT Therapy is currently being tested for use against HIV in primates. This large NIH-funded pre-clinical trial is generating promissing results for use against HIV.
Publications on Heat Biologics' ImPACT Therapy:
Discovery of ImPACT Therapy
Requirements for ImPACT Therapy (second article)
Tumor Elimination utilizing the ImPACT Therapy
The ImPACT Therapy in the Context of other Immunotherapies |
