Heat Biologics is a public biotechnology company focused on the development and commercialization of novel immunomodulators and cancer immunotherapy products. We are an innovative and growing company and have a highly energized and accomplished team.
Heat Biologics is in search of a vivarium manager to operate and maintain the vivarium and perform husbandry tasks as part of a small animal research laboratory focused drug development for oncology and autoimmunity. As part of this position, the selected candidate will also be required to perform various laboratory tasks such as dishwashing, autoclaving, and various laboratory animal support tasks associated with studies and experiments.
The primary responsibility of this position is management of the vivarium, including animal care and breeding of routine and specialized animal colonies. The position must ensure the humane, responsible, and scientifically sound use of animals, in compliance with applicable company policies, IACUC, standard operating procedures (SOPs), perform tasks in accordance with the Guide for the Care and use of Laboratory Animals, AVMA Guidelines on Euthanasia, and Federal, State and local regulations.
This role will regularly consult with the attending veterinarian and research personnel regarding animal health and welfare, and participate in the regular veterinary visits. This person will provide surgical support, treat and monitor animals in the event of health/welfare concerns under the direction/consultation with the veterinarian.
- Provide housing, husbandry, and enrichment to routine and specialized animal colonies
- Ensure that all animals are observed daily; Monitor behavior and physical attributes to ensure animal health; report to the veterinarian and group manager
- Ensure biosecurity; The candidate may not have rodents at home or work concurrently at another rodent facility or pet store. Collect samples for animal health surveillance
- Procure animals from approved vendors; receive, assign and apply animal ID numbers (microchip or other); Collect samples for genotyping
- Participate in IACUC protocol review
- Laboratory dishwashing and autoclaving associated with vivarium and laboratory operations
- Vivarium sanitation, environmental monitoring, autoclave operation, waste disposal
- Maintain accurate records regarding acquisition, housing, breeding lineage, and disposition, including room logs, health reports, cage cards, autoclave records, husbandry records, breeding records, inventory, and animal census
- Order and maintain necessary supply and equipment inventory to operate the day-to-day operations of the animal care program
- Compose daily/weekly task schedules, document task completion promptly and accurately
- Follow IACUC policies, generate and update vivarium SOPs
- Establish and maintain vivarium training documentation and schedule for research personnel
- Act as laboratory contact and backup for freezer temperature failure notifications – liquid nitrogen and deep freezer alarms; Rotate round liquid nitrogen, oxygen and CO2 tanks for freezers and incubators
- Candidate will be expected to work outside of normal business hours including weekends and holidays as required to ensure vivarium operations
- Candidate should be competent in standard scientific software used for recordkeeping and data analysis (e.g., Microsoft Excel) as well as Microsoft Word, and PowerPoint
You will work in a team and support preclinical development of novel immunology, small and large molecule, preclinical programs. The successful candidate will be an individual contributor with scientific curiosity, excellent oral and written communication skills, committed to both working independently and as part of a collaborative team. The ability to adapt to rapid changes in project priorities, define and meet aggressive timelines is necessary.
- The ideal candidate will have experience in a research facility, preferably in rodent colony management, rodent veterinary technician or research technician
- Rodent anesthesia
- Blood draws (tail vein)
- Injection techniques (i.v., i.p., p.o., subQ)
- Recording laboratory data
- Valid driver’s license
- Ability to bend, stand for extended periods of time
- Requires the ability to lift to 35 lbs. as well as move/push heavy racks a short distance
- Ability to move large liquid nitrogen tanks, CO2 and oxygen tanks for laboratory equipment
- Work environment involves some exposure to hazards or physical risks, which require basic safety precautions; The fitting and donning of a disposable N-95 respiratory mask and other personal protective equipment (PPE) is required
- No known allergies to mice
- Associates or Bachelor of Science in Animal Science or related field; or
- 5+ years breeding and husbandry experience in a laboratory animal facility and advanced AALAS certification
Knowledge in these areas are encouraged, but not required, for this position:
- Ordering animals and supplies
- Experience working with animal models of tumor growth, metastasis, providing drug treatments
- Working with inflammatory disease models such as DTH, DSS-induced colitis, CIA, EAE, dermatitis
- Necropsy and tissue processing (tumor, spleen, lymph nodes, blood)
- Experience training animal care and research technicians
- General understanding of mouse genetics and breeding for homo- and heterozygosity
- AALAS certification at the Laboratory Animal Technical level (LAT) or higher
- Experience working in an AAALAC-accredited facility
We offer a competitive compensation and benefits package as well as an environment where your contributions can make a significant difference.
Vivarium Manager I: