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Scientific Publications

Product Pipeline

Product Pipeline

  • Overview
  • HS-110
  • HS-130
  • COVID-19 Vaccine
  • PTX-35
  • Expanded Access
  • Scientific Publications
In vivo Intratumoral Electroporation of Gp96-Ig/Fc-OX40L Stimulates CD8+ T cell Cross Priming to Tumor-Specific Neoantigens Heat Biologics 2016

In vivo Intratumoral Electroporation of Gp96-Ig/Fc-OX40L Stimulates CD8+ T cell Cross Priming to Tumor-Specific Neoantigens Heat Biologics 2016

Combination Immunotherapy: T-cell costimulation (OX40L, ICOSL, and 4-1BBL) secreted locally by Gp96-Ig vaccines, elicits robust antigenspecific, memory T cell responses and tumor elimination Heat Biologics 2016

Combination Immunotherapy: T-cell costimulation (OX40L, ICOSL, and 4-1BBL) secreted locally by Gp96-Ig vaccines, elicits robust antigenspecific, memory T cell responses and tumor elimination Heat Biologics 2016

Gp96-Ig/costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T cell Priming and Enhances Immunity, Memory, and Tumor Elimination Heat Biologics 2016

Gp96-Ig/costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T cell Priming and Enhances Immunity, Memory, and Tumor Elimination Heat Biologics 2016

Combination Immunotherapy: T-cell costimulation (OX40L, ICOSL, and 4-1BBL) secreted locally by Gp96-Ig vaccines, elicits robust antigenspecific, memory T cell responses and tumor elimination Heat Biologics 2016

Combination Immunotherapy: T-cell costimulation (OX40L, ICOSL, and 4-1BBL) secreted locally by Gp96-Ig vaccines, elicits robust antigenspecific, memory T cell responses and tumor elimination Heat Biologics 2016

Locally secreted Fc-OX40L is superior to systemic, antibody mediated, OX40 co-stimulation for combination immunotherapy Heat Biologics 2016

Locally secreted Fc-OX40L is superior to systemic, antibody mediated, OX40 co-stimulation for combination immunotherapy Heat Biologics 2016

Vector Engineered Immunotherapy Incorporating gp96-Ig and T Cell Costimulatory Fusion Proteins Elicits a Superior Antigen-Specific CD8+ T Cell Response Heat Biologics 2015

Vector Engineered Immunotherapy Incorporating gp96-Ig and T Cell Costimulatory Fusion Proteins Elicits a Superior Antigen-Specific CD8+ T Cell Response Heat Biologics 2015

Immunotherapy meets epigenetics: Gp96-Ig cellular vaccine genetic signature is modulated by the inhibition of histone modifications Heat Biologics 2015

Immunotherapy meets epigenetics: Gp96-Ig cellular vaccine genetic signature is modulated by the inhibition of histone modifications Heat Biologics 2015

Comparative Combination Cancer Immunotherapy with Vaccination and TNFRSF Stimulation Heat Biologics 2014

Comparative Combination Cancer Immunotherapy with Vaccination and TNFRSF Stimulation Heat Biologics 2014

CD8 T cell response in a phase I study of therapeutic vaccination of advanced NSCLC with allogeneic tumor cells secreting endoplasmic reticulum-chaperone gp96-Ig-peptide complexes Heat Biologics 2013

CD8 T cell response in a phase I study of therapeutic vaccination of advanced NSCLC with allogeneic tumor cells secreting endoplasmic reticulum-chaperone gp96-Ig-peptide complexes Heat Biologics 2013

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