Activating the Immune System using gp96
gp96 is a key protein that serves as a natural molecular warning system:
- Potent mucosal immune memory inducer
- Chaperones antigens (pathogens or tumor) to the immune system
- Activates B cell response and drives antigen-specific CD4 and CD8 T cell activation
Heat Biologics’ Proprietary gp96 Platform
Key features:
1. Leverages gp96’s role as a natural molecular warning system
- Engineered to secrete antigens bound to gp96
2. Off-the-shelf allogeneic cell vaccine
- Feasible for large scale manufacturing
3. Broad applications in cancer treatment and vaccines for infectious diseases
4. Lead product in a Phase 2 trial for treatment of non-small cell lung cancer (NSCLC)