Technology

Activating the Immune System using gp96

Activating the Immune System using gp96

gp96 is a key protein that serves as a natural molecular warning system:

  1. Potent mucosal immune memory inducer
  2. Chaperones antigens (pathogens or tumor) to the immune system
  3. Activates B cell response and drives antigen-specific CD4 and CD8 T cell activation
Heat Biologics’ Proprietary gp96 Platform

Heat Biologics’ Proprietary gp96 Platform

Key features:

1. Leverages gp96’s role as a natural molecular warning system

  • Engineered to secrete antigens bound to gp96

2. Off-the-shelf allogeneic cell vaccine

  • Feasible for large scale manufacturing

3. Broad applications in cancer treatment and vaccines for infectious diseases

4. Lead product in a Phase 2 trial for treatment of non-small cell lung cancer (NSCLC)