Dual-acting Immunotherapy

Our Combination Pan-antigen Cytotoxic Therapy (ComPACT) is a dual-acting immunotherapy designed to deliver T-cell activation and co-stimulation in a single product.

ComPACT helps unlock the body's natural defenses and builds upon ImPACT by also providing co-stimulation to enhance T-cell activation and expansion. It has the potential to simplify combination immunotherapy development for oncology patients, as it is designed to deliver the gp96 heat shock protein and a T-cell co-stimulatory fusion protein (OX40L) into a single compound.

ComPACT offers the potential benefits of combination immunotherapy without the need for multiple, independent biologic products.

ComPACT:

  1. Enhances activation of antigen-specific “killer” CD8+ T cells
  2. Expand CD4+ T helper cells via OX40 co-stimulation
  3. Stimulates T cells to induce long-lasting memory response
  4. Localized delivery of co-stimulation to ensure safety